16:49 , Feb 13, 2018 |  BC Innovations  |  Distillery Therapeutics

Inflammation; infectious disease

INDICATION: Inflammatory disease; sepsis In vitro and mouse studies suggest inhibiting the MAC-1-CD40L interaction could help treat systemic inflammatory response syndrome (SIRS) and sepsis. In a mouse cell-based assay, a mAb against the M7 motif...
15:58 , Jun 7, 2017 |  BC Innovations  |  Distillery Therapeutics

Cardiovascular; hematology

INDICATION: Atherosclerosis; hematology Patient sample and mouse studies suggest inhibiting S100A9 could help treat diabetes-related atherosclerosis and thrombocytosis. In plasma samples from Type II diabetes patients, levels of S100A9 were higher than in samples from...
19:07 , Feb 22, 2017 |  BC Innovations  |  Distillery Therapeutics

Cardiovascular

INDICATION: Myocardial infarction (MI) Mouse studies suggest dual FPR1 / FPRL1 agonists could help treat MI. In primary rat and mouse cardiomyocyte-based models of ischemia/reperfusion, a dual FPR1/FPRL1 agonist tool compound decreased levels of the...
19:39 , Dec 6, 2016 |  BC Innovations  |  Distillery Therapeutics

Endocrine / Metabolic

INDICATION: Diabetes Patient sample and mouse studies suggest inhibiting SPT or its components, SPTLC1 or SPTLC2 , could help treat diabetes. In samples of subcutaneous adipose tissue from obese Type II diabetes patients, sphingolipid levels...
08:00 , Jan 8, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Insulin-like growth factor-1 (IGF-1) receptor (IGF1R; CD221)

Cardiovascular disease INDICATION: Heart failure; fibrillation Mouse studies suggest a hydroximic acid derivative called BGP-15 could help treat heart failure and atrial fibrillation. In a transgenic mouse model of heart failure with atrial fibrillation, orally...
07:00 , Oct 16, 2008 |  BC Innovations  |  Cover Story

Spiking diabetes

U.S. and Australian researchers have unraveled a mechanism that could explain the correlation between transient spikes in glucose levels and an increased risk for cardiovascular complications in diabetes patients. 1 The findings could change the...
07:00 , Oct 16, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Endocrine disease Diabetes NF-kB In vitro and mouse studies suggest that tight glycemic control could alleviate transient spikes in serum glucose...