00:42 , Jun 22, 2019 |  BioCentury  |  Product Development

Is tau the new amyloid?

After finally getting the message that they need to look beyond amyloid to treat Alzheimer’s disease, pharmas are lining up behind tau as the next big target. The question is whether they can pick out...
14:19 , May 14, 2019 |  BC Innovations  |  Distillery Techniques

A mouse model to screen therapies for Williams syndrome

TECHNIQUES CATEGORY: Disease models TECHNOLOGY: Transgenics and knockouts GTF2I-deficient mice could be used to screen therapies for Williams syndrome, which is caused by gene deletions on chromosome 7 that lead to learning and cardiovascular problems....
23:41 , May 1, 2019 |  BC Innovations  |  Translation in Brief

White matter matters in Alzheimer’s

An MIT team has identified Alzheimer’s disease-associated changes in gene expression that vary based on cell type, including myelin-related genes, suggesting new pathways that can be explored to treat the disease. Described in a Nature...
13:56 , Apr 10, 2019 |  BC Innovations  |  Distillery Therapeutics

Blocking the ATAD3A-DNM1L interaction for HD

DISEASE CATEGORY: Neurology INDICATION: Huntington disease (HD) Cell culture and mouse studies identified an inhibitor of ATAD3A-DNM1L interaction that could help treat HD. An in vitro assay for proteins that bind DNM1L identified ATAD3A as...
21:48 , Apr 2, 2019 |  BC Innovations  |  Distillery Therapeutics

Conbriza bazedoxifene for MS and other demyelinating diseases

DISEASE CATEGORY: Autoimmune disease; neurology INDICATION: Multiple sclerosis (MS); neurology Cell culture and mouse studies suggest Conbriza bazedoxifene could help treat MS and other demyelinating diseases. In oligodendrocyte precursor cells (OPCs) derived from a human...
13:05 , Mar 13, 2019 |  BC Innovations  |  Distillery Therapeutics

Inhibiting PIEZO1 for nerve damage

DISEASE CATEGORY: Neurology INDICATION: Nerve damage Fruit fly and mouse studies suggest inhibiting PIEZO1 could help treat nerve damage. In two Drosophila models of sensory nerve injury and one Drosophila model of motor nerve injury,...
15:48 , Feb 28, 2019 |  BC Innovations  |  Distillery Therapeutics

Neurology; inflammation

INDICATION: Stroke; shock/trauma Patient and mouse studies suggest inhibiting CCR5 could help treat stroke and traumatic brain injury (TBI). In stroke patients, the absence of a loss-of-function mutant CCR5 allele was associated with the severity...
01:17 , Feb 16, 2019 |  BC Extra  |  Company News

Emerging company roundup: Passage, IFM, Grey Wolf, Culture

In a week that had a pair of innovative Chinese companies raise early venture rounds and a Bay Area company debut its digital biomanufacturing platform, the biggest series A round went to Philadelphia gene therapy...
18:23 , Feb 15, 2019 |  BC Week In Review  |  Company News

Axovant spins out small molecule team to form CNS-focused newco

Following its pivot to gene therapy, Axovant Sciences Ltd. (NASDAQ:AXON) has spun out its small molecule team into Arvelle Therapeutics GmbH (Basel, Switzerland). The newco has raised more than $100 million and in-licensed exclusive European...
23:28 , Feb 14, 2019 |  BC Extra  |  Company News

Axovant spins out small molecule team to form CNS-focused newco

Following its pivot to gene therapy, Axovant Sciences Ltd. (NASDAQ:AXON) has spun out its small molecule team into Arvelle Therapeutics GmbH (Basel, Switzerland). The newco has raised more than $100 million and in-licensed exclusive European...