14:21 , Apr 18, 2017 |  BC Innovations  |  Distillery Techniques

Assays and screens

TECHNOLOGY: Diagnostic assays; cell-free assays A rapid, magnetic particle-based method of isolating extracellular vesicles could aid the development of cancer diagnostics. The 15-minute method involves labeling extracellular vesicles in patient plasma samples with a probe...
07:00 , Oct 22, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Delta-like 1 (DLL1); immunoglobulin G (IgG)

Cancer INDICATION: Lung cancer Studies in mice suggest complexes of DLL1 , biotinylated anti-IgG antibodies and the biotin-binding protein avidin could help treat lung cancer. In mouse xenograft models of lung cancer, multiple complexes consisting...
07:00 , Sep 1, 2011 |  BC Innovations  |  Targets & Mechanisms

Notch one for activating NOTCH

Multiple studies in recent years have called into question the use of NOTCH inhibitors to treat cancer because of an increased risk of endothelial cell tumors seen in animal models. 1 Now, researchers at Vanderbilt...
07:00 , Jun 27, 2011 |  BC Week In Review  |  Clinical News

EP217609: Phase IIa started

Endotis began the Phase IIa NOVEL trial to compare EP217609 and its specific antidote avidin vs. heparin in 36 patients undergoing cardiac surgery. Endotis has rights to EP217609 from Merck. Endotis Pharma , Romainville, France...
08:00 , Dec 6, 2010 |  BC Week In Review  |  Clinical News

EP217609: Additional Phase I data

Additional data from a French Phase I trial in 36 healthy volunteers showed that a single IV bolus injection of EP217609 achieved stable anticoagulation during 90 minutes. Subsequent administration of EP217609's specific antidote avidin triggered...
08:00 , Dec 2, 2010 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Targeted leukemia inhibitory factor (LIF)-loaded nanoparticles to modulate CD4+ T cell maturation for immunotherapy Studies in mice and in cell culture...
07:00 , Jul 12, 2010 |  BC Week In Review  |  Clinical News

Endotis, Merck preclinical data

In a canine model of ECC, a single dose of EP217609 produced stable anticoagulation throughout an ECC procedure. Subsequent administration of EP217609's specific antidote avidin produced rapid, irreversible neutralization with no rebound effect. Data were...
07:00 , Jun 4, 2007 |  BC Week In Review  |  Clinical News

Ark preclinical data

Rats receiving Scavidin plus a low dose of IV yttrium-90 survived 32% longer than animals receiving yttrium-90 alone or controls. AKT said the dose of yttrium-90 would typically be subtherapeutic. Scavidin is a fusion protein...
08:00 , Jan 20, 2003 |  BioCentury  |  Tools & Techniques

Avoiding colonoscopy

SNP detection can be used to diagnose cancers and other diseases, but it is impractical in situations where mutations are numerous and distributed throughout the gene rather than confined to a single region. Other techniques...
07:00 , Jul 29, 2002 |  BC Week In Review  |  Company News

University of California other research news

Researchers published in the Proceedings of the National Academy of Sciences evidence for the use of anti-TfR-Av in treating cancer. In culture, anti-TfR-Av showed anti-proliferative activity in both rat and human cancer cell lines. Researchers...