13:47 , Jan 3, 2019 |  BC Innovations  |  Distillery Therapeutics

Cancer; gastrointestinal; inflammation

INDICATION: Breast cancer; colitis; asthma Mouse studies suggest inhibiting SPR could help treat colitis and asthma, and its biosynthetic product THB could help treat breast cancer. In a xenograft mouse model of breast cancer, THB...
00:39 , Feb 1, 2018 |  BC Innovations  |  Emerging Company Profile

Non-adherence policy

Having worked out how to make non-adherent primary cells amenable to microscopy, Allcyte GmbH has created a platform for imaging interactions between T cells and B cells that can predict drug responses in hematological cancers....
02:10 , Dec 8, 2017 |  BC Innovations  |  Targets & Mechanisms

Epiphenomena at ASH

While it’s no surprise that cell therapy research is dominant in hematology, the emergence of epigenetics as an equally large focus at this year’s ASH meeting is more notable, reinforcing the resurgence of a field...
23:38 , Oct 24, 2017 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Cell models A biobank of insertional mutagenesis-derived haploid mouse ESCs could be used to link genes to disease-related phenotypes in homogeneous cell populations. The biobank consists of over 100,000 haploid mouse ESCs with genetically...
03:49 , Sep 28, 2017 |  BC Extra  |  Preclinical News

Researchers report first Haplobank data

In a paper published in Nature , researchers at the Austrian Academy of Sciences and colleagues reported the first data from Haplobank, an open-access haploid mouse embryonic stem cell (ESC) bank created in collaboration with...
20:31 , May 23, 2017 |  BC Innovations  |  Distillery Techniques

Assays and screens; imaging

TECHNOLOGY: Cellular assays; fluorescence An automated fluorescence microscopy method for detecting cell-cell interactions in human peripheral blood mononuclear cells (PBMCs) could be used to screen for immunomodulatory compounds. The method involved automated spinning disc confocal...
19:49 , Feb 23, 2017 |  BC Innovations  |  Translation in Brief

Folded brain

As organoids become increasingly sophisticated tools for preclinical research, a team led by mouse genetics guru Rudolf Jaenisch has developed an organoid model of the cerebrum containing surface folding that recapitulates the brain structure in...
23:05 , Jan 3, 2017 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Gram-negative bacterial infection; sepsis Cell culture and mouse studies suggest quinine could help treat Gram-negative bacteria-associated sepsis in patients with hemolytic disorders. Screening of a small molecule library in a mouse macrophage-based assay of...
07:00 , May 12, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Receptor-interacting serine-threonine kinase 3 (RIPK3; RIP3); tumor necrosis factor receptor 1 (TNFRSF1A; TNFR1; CD120a); HECT domain and ankyrin

Cancer INDICATION: Colorectal cancer; cancer Mouse studies suggest inhibiting TNFRSF1A or RIPK3 could help treat colon and other cancers harboring loss-of-function HACE1 mutations. In a mouse model of HACE1-mutant colon cancer, systemic knockout of TNFRSF1A...
07:00 , May 22, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Neurology Cleavage and polyadenylation factor 1 subunit 1 (CLP1) Studies in patients and mice identified a mutation in CLP1 that causes CNS dysfunction. A homozygous...