22:41 , Jun 20, 2019 |  BC Innovations  |  Targets & Mechanisms

Moving beyond the active site: why allostery is newly in fashion

A new crop of companies is creating tools to systematize development of allosteric protein inhibitors, finally moving industry beyond the one-off compounds that have been found by accident. Allosteric pockets on proteins have long been...
00:11 , Jun 14, 2019 |  BC Extra  |  Clinical News

June 13 Clinical Quick Takes: Roche's Gazyva meets in Phase II for lupus; plus Boehringer/Lilly, Savara and more

Roche's Gazyva clears Phase II hurdle in lupus nephritis  Gazyva obinutuzumab from Roche (SIX:ROG; OTCQX:RHHBY) met the primary endpoint in the Phase II NOBILITY trial to treat lupus nephritis. Given in combination with standard of...
17:51 , May 28, 2019 |  BC Innovations  |  Distillery Therapeutics

Split intein-based gene therapies for two types of congenital blindness

DISEASE CATEGORY: Ophthalmic disease INDICATION: Blindness Mouse studies suggest gene therapies delivering ABCA4 or CEP290 as split inteins could help treat Stargardt disease or Leber congenital amaurosis type 10 (LCA10), respectively. The therapies consist of...
12:00 , May 20, 2019 |  BioCentury  |  Emerging Company Profile

Reneo: Small molecules for rare mitochondrial diseases

With a $50 million series A led by NEA and a management team guided by veterans of Shire takeout Lumena, Reneo believes its small molecule could carve out a niche in the rare genetic mitochondrial...
19:42 , May 6, 2019 |  BC Extra  |  Financial News

May 6 Financial Quick Takes: Athenex, Spiral

Athenex raises $100M to advance Oraxol  Looking to fund commercialization activities for Oraxol and advance its oncology pipeline and actinic keratosis therapy, Athenex Inc. (NASDAQ:ATNX) raised $100 million in a private placement through the sale...
17:44 , Apr 5, 2019 |  BC Week In Review  |  Clinical News

Black Diamond maps new class of glioblastoma mutations

Black Diamond showed in preclinical data presented at the American Association for Cancer Research (AACR) meeting why some EGFR mutations in glioblastoma multiforme (GBM) do not respond to early generation kinase inhibitors. The mutations occur...
22:30 , Apr 4, 2019 |  BC Extra  |  Preclinical News

Nimbus exposes complete ACLY structure, discovers allosteric inhibitory sites

Nimbus is spinning out a subsidiary to develop ACLY inhibitors targeting a new allosteric site on the enzyme that it discovered in collaboration with Schrödinger and Columbia University. BioCentury identified lipid biosynthesis regulator ACLY as...
02:24 , Mar 29, 2019 |  BC Innovations  |  Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

New and emerging targets at AACR 2019 show cancer researchers are gaining granularity on how to manipulate the tumor microenvironment, a top priority goal for the field. The targets point to emerging strategies for modulating...
17:36 , Mar 8, 2019 |  BC Week In Review  |  Company News

Esperion submits NDAs to FDA for LDL-C lowering products, EMA starts review

Esperion said it submitted two NDAs to FDA for bempedoic acid (ETC-1002) and a bempedoic acid/ezetimibe combination tablet to treat elevated LDL-C in patients who need additional LDL-C lowering despite the use of currently accessible...
14:41 , Mar 7, 2019 |  BC Innovations  |  Translation in Brief

Blocking B cell vesicles to enhance chemotherapy

Blocking extracellular vesicles derived from B cells could offer a new therapeutic avenue to enhance the efficacy of chemotherapy for cancer, according to a Zhejiang University study. Chemotherapy reduces antitumor immunity by inducing systemic immunosuppression....