18:38 , Oct 18, 2018 |  BC Innovations  |  Distillery Therapeutics

Endocrine/Metabolic

INDICATION: Porphyria In vitro , cell culture and mouse studies suggest ciclopirox could help treat congenital erythropoietic porphyria (CEP), which is caused by destabilizing mutations in UROS. Fragment-based screening, structural comparison of the top screening...
20:38 , Oct 17, 2018 |  BC Innovations  |  Translation in Brief

Ciclopirox the chaperone

Atlas Molecular Pharma S.L. plans to repurpose antifungal drug ciclopirox to treat congenital erythropoietic porphyria after discovering it allosterically stabilizes an enzyme driving the disease. Atlas and colleagues from Center for Cooperative Research in Biosciences...