08:00 , Dec 12, 2013 |  BC Innovations  |  Targets & Mechanisms

ClpPing persistence

Northeastern University researchers have combined traditional antibiotics with compounds that activate bacterial clpP protease and cured mice with severe, highly drug-resistant Staphylococcus biofilm infections. 1 Arietis Corp. is developing analogs of the compounds to treat...
08:00 , Dec 12, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Staphylococcus ClpP Cell culture and mouse studies suggest combining the antibiotic acyldepsipeptide 4 (ADEP4) with rifampicin could help eradicate biofilms....