19:35 , Jan 18, 2019 |  BioCentury  |  Emerging Company Profile

Achilles’ truncal neoantigens

Achilles Therapeutics Ltd. is developing a personalized T cell therapy that uses “truncal” neoantigens expressed in all tumor cells to drive T cells selected from tumor-infiltrating lymphocytes (TILs). Neoantigen discovery is fueling a burst of...
17:10 , Jan 16, 2019 |  BC Innovations  |  Distillery Techniques

Imaging; other

TECHNOLOGY: Other; computational models A machine-learning algorithm for analyzing digitized film images of the cervix could help diagnose cervical intraepithelial neoplasia (CIN) lesions of grade 2 or higher (CIN 2 or CIN >2), which are...
00:04 , Jan 16, 2019 |  BC Extra  |  Tools & Techniques

Researchers develop AI tool to improve screening for cervical cancer

A team from NCI and Intellectual Ventures Global Good Fund released a paper Thursday detailing an image-based, machine-learning algorithm that improves screening accuracy for precancerous cervical lesions. The tool could help reduce the incidence of...
21:41 , Jan 10, 2019 |  BC Innovations  |  Translation in Brief

Guided design for CRISPR editing

Separate teams from the Wellcome Sanger Institute and The Francis Crick Institute have developed an algorithm and identified a set of genetic features, respectively, that could help drug developers improve the safety of CRISPR-Cas9-based therapies...
01:06 , Jan 8, 2019 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: Gene profiling; tissue markers Sex-specific gene expression signatures could help predict response to chemotherapy in glioblastoma patients. In glioblastoma tissue samples from male and female patients receiving SOC (surgery, radiation and chemotherapy), application of...
07:01 , Dec 18, 2018 |  BC Extra  |  Tools & Techniques

Gritstone showcases mass spec-based neoantigen discovery platform

Gritstone Oncology Inc. (NASDAQ:GRTS) unveiled the inner workings of its mass spectrometry-based neoantigen identification platform, EDGE, in a Nature Biotechnology study published Monday. Results from the paper suggest building a machine-learning algorithm based on human...
03:50 , Dec 1, 2018 |  BioCentury  |  Product Development

Cell therapy momentum at ASH

This year’s American Society of Hematology (ASH) meeting will showcase a surge in clinical CAR T cell presentations. But gene therapies are not following the same trajectory, despite both modalities being fresh off their first...
04:22 , Nov 8, 2018 |  BC Extra  |  Preclinical News

Machine learning tool predicts template-free CRISPR editing

CRISPR veteran David Liu of the Broad Institute of MIT and Harvard and colleagues have developed a machine learning algorithm that predicts the genotypic result of CRISPR-mediated DNA breaks, suggesting CRISPR-based editing could be achieved...
00:05 , Oct 26, 2018 |  BC Innovations  |  Tools & Techniques

Deconstructing the rule of five

The concept of drug-like properties has come under fire from a Novartis AG study that found the last 20 years of drugs have not conformed to the rule of five. Showing the rule’s principles have...
18:19 , Oct 18, 2018 |  BC Innovations  |  Distillery Techniques

Imaging; other

TECHNOLOGY: Other; computational models A machine learning algorithm that analyzes digital CT scans could help identify invasive, early stage lung cancers. The algorithm was trained on a set of 3-D, 32 mm patches of CT...