04:22 , Nov 8, 2018 |  BC Extra  |  Preclinical News

Machine learning tool predicts template-free CRISPR editing

CRISPR veteran David Liu of the Broad Institute of MIT and Harvard and colleagues have developed a machine learning algorithm that predicts the genotypic result of CRISPR-mediated DNA breaks, suggesting CRISPR-based editing could be achieved...
00:05 , Oct 26, 2018 |  BC Innovations  |  Tools & Techniques

Deconstructing the rule of five

The concept of drug-like properties has come under fire from a Novartis AG study that found the last 20 years of drugs have not conformed to the rule of five. Showing the rule’s principles have...
18:19 , Oct 18, 2018 |  BC Innovations  |  Distillery Techniques

Imaging; other

TECHNOLOGY: Other; computational models A machine learning algorithm that analyzes digital CT scans could help identify invasive, early stage lung cancers. The algorithm was trained on a set of 3-D, 32 mm patches of CT...
19:19 , Oct 11, 2018 |  BC Innovations  |  Distillery Techniques

Assays and screens; biomarkers

TECHNOLOGY: Cellular assays; tissue markers A tissue-based gene signature for quantifying immune cells could help identify populations of immune cell types as diagnostic or prognostic markers of disease. Identification of the signature, dubbed ImSig, involved...
19:19 , Oct 11, 2018 |  BC Innovations  |  Distillery Techniques

Other

TECHNOLOGY: Computational models A sequence motif-based algorithm for predicting lncRNA function could help identify new drug targets. For a set of lncRNAs, the algorithm quantifies the number of sequences of a defined base length (k-mers)...
19:15 , Oct 11, 2018 |  BC Innovations  |  Translation in Brief

Profiling long non-coding RNA function

A team at the University of North Carolina at Chapel Hill has developed a computational algorithm to predict the functions of long non-coding RNAs, an advance that could eventually lead to the development of therapeutics...
17:36 , Sep 21, 2018 |  BC Week In Review  |  Company News

Roivant launches respiratory vant, announces other vant news

Roivant Sciences GmbH (Basel, Switzerland) announced the launch of a new respiratory disease subsidiary, a real-world evidence partnership between its Datavant Inc. (San Francisco, Calif.) subsidiary and CRO Parexel International Corp. (Waltham, Mass.), and its...
16:42 , Sep 19, 2018 |  BC Innovations  |  Distillery Techniques

Assays and screens; biomarkers; other

TECHNOLOGY: Bioinformatics; gene profiling; computational models Computational models based on tumor levels of lncRNAs could help predict resistance to cancer therapies. The method involves a machine learning algorithm that uses the expression levels of 2,614...
23:37 , Sep 17, 2018 |  BC Extra  |  Tools & Techniques

AI code could speed cancer diagnosis, treatment decisions

New York University School of Medicine researchers described in...
21:36 , Sep 17, 2018 |  BC Extra  |  Company News

Roivant launches respiratory vant, announces other vant news

Roivant Sciences GmbH (Basel, Switzerland) had a busy Monday announcing the launch of a new respiratory disease subsidiary, a real-world evidence partnership between its Datavant Inc. (San Francisco, Calif.) subsidiary and CRO Parexel International Corp....