19:43 , Aug 31, 2018 |  BC Week In Review  |  Clinical News

Pfizer ends Phase II trials of DMD candidate

Pfizer Inc. (NYSE:PFE) terminated two Phase II trials of domagrozumab (PF-06252616) to treat Duchenne muscular dystrophy after one of the studies missed its primary endpoint. The company will evaluate the data to determine next steps...
15:47 , Aug 30, 2018 |  BC Extra  |  Clinical News

Pfizer ends Phase II trials of DMD candidate

Pfizer Inc. (NYSE:PFE) terminated two Phase II trials of domagrozumab (PF-06252616) to treat Duchenne muscular dystrophy after one of the studies missed its primary endpoint. The company will evaluate the data to determine next steps...
16:35 , Aug 3, 2018 |  BC Week In Review  |  Clinical News

Acceleron's ACE-083 increases muscle volume in Phase II for Charcot-Marie-Tooth disease

Acceleron Pharma Inc. (NASDAQ:XLRN) reported preliminary data from 18 patients with Charcot-Marie-Tooth disease in Part 1 of a Phase II trial showing that ACE-083 increased mean total muscle volume by 12.6-14.2%, increased mean contractile muscle...
20:06 , Aug 1, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Lung cancer Patient sample, cell culture and mouse studies suggest inhibiting activin signaling could enhance the efficacy of platinum-based chemotherapy in KRAS-mutant lung cancer. In 59 patients with stage IV non-small cell lung cancer (NSCLC)...
19:24 , Jul 13, 2018 |  BC Week In Review  |  Clinical News

Acceleron, Celgene score second win with latest luspatercept readout

Acceleron Pharma Inc. (NASDAQ:XLRN) climbed $1.36 to $48.76 July 10 after it and partner Celgene Corp. (NASDAQ:CELG) said luspatercept (ACE-536) met the primary endpoint in the Phase III BELIEVE study to treat beta-thalassemia. The companies...
17:34 , Jul 10, 2018 |  BC Extra  |  Clinical News

Latest luspatercept readout a second win for Acceleron, Celgene

Acceleron Pharma Inc. (NASDAQ:XLRN) climbed $1.36 to $48.76 Tuesday after it and partner Celgene Corp. (NASDAQ:CELG) said luspatercept (ACE-536) met the primary endpoint in the Phase III BELIEVE study to treat beta-thalassemia. The companies are...
20:29 , Jul 6, 2018 |  BC Extra  |  Company News

Management tracks: Goldman Sachs, Acceleron

One of China's top healthcare analysts, Richard Yeh, said he is departing Goldman Sachs, where he was in global investment research for Asia Pacific. Several Asia-focused bankers and analysts, including Citigroup's Billy Cho, Bank of...
03:04 , Jun 30, 2018 |  BioCentury  |  Finance

Eyes on launches

The annual summer slowdown isn’t restricted to just the stock market this year, as the clinical catalyst calendar also appears to be on holiday in 3Q18. Buysiders are therefore turning their attention to a spate of...
18:26 , Jun 29, 2018 |  BC Week In Review  |  Clinical News

Celgene, Acceleron planning submissions for luspatercept

Celgene Corp. (NASDAQ:CELG) and Acceleron Pharma Inc. (NASDAQ:XLRN) said luspatercept (ACE-536) met the primary endpoint in the Phase III MEDALIST trial to treat myelodysplastic syndrome (MDS). The partners plan to submit regulatory applications in the...
22:58 , Jun 28, 2018 |  BC Extra  |  Clinical News

Celgene, Acceleron planning submissions for luspatercept

Celgene Corp. (NASDAQ:CELG) and Acceleron Pharma Inc. (NASDAQ:XLRN) said luspatercept (ACE-536) met the primary endpoint in the Phase III MEDALIST trial to treat myelodysplastic syndrome (MDS). The partners plan to submit regulatory applications in the...