01:19 , Dec 13, 2017 |  BC Innovations  |  Distillery Techniques

Chemistry

TECHNOLOGY: Tool compounds A peptidyl ketoamide-based covalent inhibitor of five bacterial rhomboid proteases could help probe the role the enzymes in bacterial infections. Chemical synthesis and in vitro testing in enzyme activity assays of peptidyl ketoamide...
18:00 , Aug 16, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Cognitive dysfunction; neurology Mouse and pig studies identified a GLS inhibitor prodrug that could help treat HIV-associated neurocognitive disorders. In a mouse model of HIV-associated neurocognitive dysfunction, the GLS inhibitor 6-diazo-5-oxo-L-norleucine (DON) increased spatial learning...
18:38 , Aug 9, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Pain Mouse and rat studies identified a prodrug of a PSMA inhibitor that could help treat neuropathic pain. The compound contained a hydroxyamine-benzenepropanoic acid-based PSMA inhibitor (IC50 = 44 nM) modified at the hydrozyamine with...
07:00 , May 14, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Phosphatidylinositol 4-kinase catalytic β (PI4KB; PI4KIIIβ)

Infectious disease INDICATION: Viral infection In vitro studies suggest inhibitors of PI4KB could help treat RNA virus infections. Chemical synthesis and in vitro testing of pyrazolopyrimidine analogs identified multiple compounds that selectively inhibited PI4KB with IC50 values...
07:00 , Jun 11, 2012 |  BC Week In Review  |  Company News

Enamine, Academy of Sciences, Medical Research Council Laboratory of Mol Biology deal

Enamine will provide MRC LMB and the academy's Institute of Organic Chemistry and Biochemistry access to screening technologies to discover small molecule rhomboid protease inhibitors to treat infectious diseases, cancer, and autoimmune and cardiovascular indications....
08:00 , Mar 8, 2012 |  BC Innovations  |  Targets & Mechanisms

Repowering the ovary

Researchers at Massachusetts General Hospital and Harvard Medical School have devised a protocol to identify and isolate a population of human germline stem cells that give rise to viable oocytes.1 Although reports in the general...
07:00 , Aug 1, 2011 |  BC Week In Review  |  Company News

Gilead, The Academy of Sciences of the Czech Republic deal

Gilead disclosed in its 2Q11 earnings that in May it extended for an additional five years its 2006 deal to provide funding support for the Gilead Sciences Research Center at the Institute of Organic Chemistry...
07:00 , Jul 28, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Not applicable In vitro and mouse studies suggest 7-hetaryl-7-deazaadenosine-derived compounds could help treat cancer. In a...
08:00 , Jan 7, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer RNA Studies in cell culture identified 7-deazapurine purine nucleoside-based inhibitors of RNA synthesis that could help...
08:00 , Dec 6, 1999 |  BioCentury  |  Tools & Techniques

Gilead: Defending the class

Gilead Sciences Inc.'s announcement late Friday that it will discontinue U.S. development of adefovir dipivoxil to treat HIV comes as no surprise. But the company maintains that the problems that led the FDA's Antiviral Drugs...