16:44 , Sep 19, 2018 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs SNPs on PKN1, DOK2 and APOB could help predict the risk of pancreatic ductal adenocarcinoma (PDAC) in the Chinese population. In 943 PDAC patients and 3,908 healthy volunteers of Chinese descent, whole-exome screening identified...
22:07 , Sep 13, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: August 2018

New Therapeutic Targets and Biomarkers: August 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in August 2018. Therapeutic targets are defined as any protein, gene or other molecule...
16:09 , Aug 16, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Zika virus Cell culture studies suggest promoting PARP-12 expression could help treat Zika infection. In human lung epithelial cell line-based stability assays of Zika virus non-structural protein NS1 (Zika NS1) or NS3, PARP-12 encoded...
17:38 , Jul 17, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Multiple myeloma (MM) Patient sample and mouse studies suggest inhibiting NEK2 could help treat Velcade bortezomib-resistant MM. In MM patients, high levels of NEK2 in bone marrow plasma cells were associated with poor overall and...
17:53 , Jun 28, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Cancer; gastric cancer; lung cancer; brain cancer In vitro, cell culture and mouse studies identified four methylquinazoline-based PI3K inhibitors that could help treat cancer. Chemical synthesis of methylquinazoline analogs and in vitro enzyme activity assays...
05:50 , Jun 2, 2018 |  BioCentury  |  Product Development

Breaking from the herd

Behind the block of clinical studies on PD-1 and PD-L1 inhibitors, researchers are casting aside their herd mentality with a wide net of strategies to solve some of the most pressing problems in oncology, such...
22:46 , Apr 24, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Pneumonia Mouse studies suggest inhibiting IP6K1 could help treat bacterial pneumonia. In mouse models of E. coli- or Staphylococcus aureus-induced pneumonia, systemic IP6K1 knockout decreased bacterial burden, edema and neutrophil infiltration in the lung, and...
20:01 , Feb 1, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: January 2018

New Therapeutic Targets and Biomarkers: January 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during January 2018. Therapeutic targets are defined as any protein, gene or other molecule...
19:24 , Jan 17, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Viral infection Cell culture and mouse studies suggest inhibiting TRIM40 could help treat viral infections. In mouse embryonic fibroblasts infected with vesicular stomatitis virus, knockout of TRIM40 knockout decreased viral replication compared with normal TRIM40...
16:05 , Jun 7, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Melanoma Mouse studies suggest combing IFNγ with ARH inhibition could help treat melanoma. In an immunodeficient mouse model of melanoma, IFNγ plus an ARH inhibitor tool compound decreased tumor growth and the number of cancer...