23:12 , May 9, 2019 |  BC Extra  |  Tools & Techniques

Chinese bioethicists call for ‘reboot’ of regulations following CRISPR babies

Four bioethics professors from prominent Chinese universities proposed steps that could "reboot" research ethics in China including top-down regulation and increased bioethics training. The need for ethical reforms for China's clinical trial system was highlighted...
20:15 , Mar 25, 2019 |  BC Innovations  |  Distillery Techniques

AHR levels in tumors predict response to Keytruda and other anti-PD-1 therapies in NSCLC

TECHNIQUES CATEGORY: Biomarkers TECHNOLOGY: Tissue markers Tumor levels of AHR could help predict response to Keytruda pembrolizumab and other PD-1 inhibitors in NSCLC. In 37 patients treated with Keytruda, high tumor levels of AHR protein...
20:02 , Feb 14, 2019 |  BC Extra  |  Politics & Policy

Hamburg to co-chair WHO human genome editing committee

Margaret Hamburg will co-chair a newly formed WHO advisory committee to develop global standards for human genome editing governance. The WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome...
23:17 , Oct 3, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: September 2018

New Therapeutic Targets and Biomarkers: September 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in September. Therapeutic targets are defined as any protein, gene or other molecule...
16:44 , Sep 19, 2018 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs SNPs on PKN1, DOK2 and APOB could help predict the risk of pancreatic ductal adenocarcinoma (PDAC) in the Chinese population. In 943 PDAC patients and 3,908 healthy volunteers of Chinese descent, whole-exome screening...
22:07 , Sep 13, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: August 2018

New Therapeutic Targets and Biomarkers: August 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in August 2018. Therapeutic targets are defined as any protein, gene or other...
16:09 , Aug 16, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Zika virus Cell culture studies suggest promoting PARP-12 expression could help treat Zika infection. In human lung epithelial cell line-based stability assays of Zika virus non-structural protein NS1 (Zika NS1) or NS3, PARP-12 encoded...
17:38 , Jul 17, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Multiple myeloma (MM) Patient sample and mouse studies suggest inhibiting NEK2 could help treat Velcade bortezomib-resistant MM. In MM patients, high levels of NEK2 in bone marrow plasma cells were associated with poor overall...
17:53 , Jun 28, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Cancer; gastric cancer; lung cancer; brain cancer In vitro , cell culture and mouse studies identified four methylquinazoline-based PI3K inhibitors that could help treat cancer. Chemical synthesis of methylquinazoline analogs and in vitro enzyme...
05:50 , Jun 2, 2018 |  BioCentury  |  Product Development

Breaking from the herd

Behind the block of clinical studies on PD-1 and PD-L1 inhibitors, researchers are casting aside their herd mentality with a wide net of strategies to solve some of the most pressing problems in oncology, such...