BioCentury | Aug 23, 2018
Distillery Therapeutics

Neurology

...sample and rabbit studies suggest estradiol could help treat neurobehavioral disorders associated with defects in interneuron...
...and protein levels of aristaless related homeobox (ARX) -- a transcription factor that regulates cortical interneuron...
...with vehicle. Next steps could include testing the effect of estradiol on behaviors related to interneuron...
BioCentury | Aug 17, 2018
Company News

BioMotiv, Cure Network developing inhibitory interneuron small molecules

...focus on research from the lab of Jorge Palop, which has shown that enhancing inhibitor interneuron...
BioCentury | May 3, 2018
Preclinical News

Optogenetic cochlea implants to treat hearing loss

In a Nature Communications paper , scientists at Max Planck Institute of Biophysics and colleagues suggested that optogenetic cochlear implants that use a light-stimulated ion channel engineered with increased neural photoactivation could help treat hearing loss....
BioCentury | Oct 5, 2017
Translation in Brief

SSRIs' first responders

Researchers at The Rockefeller University have identified a role for CCK-expressing neurons in initiating responses to SSRIs for depression and manipulated the neurons to recapitulate the drugs' effects. The findings could lead to faster-acting antidepressants...
BioCentury | May 8, 2017
Distillery Techniques

Drug platforms

...of HPSCs into V2a interneurons, as measured by the percentage of hESCs expressing a V2a interneuron...
BioCentury | Apr 25, 2017
Clinical News

Interneuron strategy could lead to cell therapy for SCI

A team led by scientists at the Gladstone Institutes is the first to develop a cell culture strategy to generate V2a interneurons from human pluripotent stem cells (hPSCs), which could be used as a cell...
BioCentury | Mar 9, 2015
Finance

Column's creations

Including milestones, Bristol-Myers Squibb Co .'s takeout of Flexus Biosciences Inc. late last month is enough to return the capital of The Column Group's entire second fund. While it's the third quick exit for TCG,...
BioCentury | Jan 29, 2015
Distillery Techniques

Techniques: Mouse model of Tourette's syndrome

...in the brain region, reflecting the pathophysiology of Tourette's syndrome in humans. In mice with interneuron...
BioCentury | Aug 14, 2014
Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Parkinson's disease (PD) a-synuclein (SNCA) Mouse and cell culture studies have identified antibodies against the SNCA C terminus that could help stabilize SNCA and treat...
BioCentury | Jun 5, 2014
Distillery Therapeutics

Indication: Cancer

...GABA)-containing interneurons could help treat schizophrenia. In a mouse model of schizophrenia, grafting live GABAergic interneuron...
...testing GABAergic interneuron transplantation in other schizophrenia models and developing pharmacological strategies to increase GABAergic interneuron...
Items per page:
1 - 10 of 571
BioCentury | Aug 23, 2018
Distillery Therapeutics

Neurology

...sample and rabbit studies suggest estradiol could help treat neurobehavioral disorders associated with defects in interneuron...
...and protein levels of aristaless related homeobox (ARX) -- a transcription factor that regulates cortical interneuron...
...with vehicle. Next steps could include testing the effect of estradiol on behaviors related to interneuron...
BioCentury | Aug 17, 2018
Company News

BioMotiv, Cure Network developing inhibitory interneuron small molecules

...focus on research from the lab of Jorge Palop, which has shown that enhancing inhibitor interneuron...
BioCentury | May 3, 2018
Preclinical News

Optogenetic cochlea implants to treat hearing loss

In a Nature Communications paper , scientists at Max Planck Institute of Biophysics and colleagues suggested that optogenetic cochlear implants that use a light-stimulated ion channel engineered with increased neural photoactivation could help treat hearing loss....
BioCentury | Oct 5, 2017
Translation in Brief

SSRIs' first responders

Researchers at The Rockefeller University have identified a role for CCK-expressing neurons in initiating responses to SSRIs for depression and manipulated the neurons to recapitulate the drugs' effects. The findings could lead to faster-acting antidepressants...
BioCentury | May 8, 2017
Distillery Techniques

Drug platforms

...of HPSCs into V2a interneurons, as measured by the percentage of hESCs expressing a V2a interneuron...
BioCentury | Apr 25, 2017
Clinical News

Interneuron strategy could lead to cell therapy for SCI

A team led by scientists at the Gladstone Institutes is the first to develop a cell culture strategy to generate V2a interneurons from human pluripotent stem cells (hPSCs), which could be used as a cell...
BioCentury | Mar 9, 2015
Finance

Column's creations

Including milestones, Bristol-Myers Squibb Co .'s takeout of Flexus Biosciences Inc. late last month is enough to return the capital of The Column Group's entire second fund. While it's the third quick exit for TCG,...
BioCentury | Jan 29, 2015
Distillery Techniques

Techniques: Mouse model of Tourette's syndrome

...in the brain region, reflecting the pathophysiology of Tourette's syndrome in humans. In mice with interneuron...
BioCentury | Aug 14, 2014
Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Parkinson's disease (PD) a-synuclein (SNCA) Mouse and cell culture studies have identified antibodies against the SNCA C terminus that could help stabilize SNCA and treat...
BioCentury | Jun 5, 2014
Distillery Therapeutics

Indication: Cancer

...GABA)-containing interneurons could help treat schizophrenia. In a mouse model of schizophrenia, grafting live GABAergic interneuron...
...testing GABAergic interneuron transplantation in other schizophrenia models and developing pharmacological strategies to increase GABAergic interneuron...
Items per page:
1 - 10 of 571