BioCentury | Jun 11, 2020
Deals

Prism’s peptide mimetic platform finds second discovery partner

...Ingelheim GmbH, which has options to license and develop any resulting compounds. Prism’s library comprises α-helix...
...estimate which part of the target protein’s amino acid sequence is likely to form a helix...
BioCentury | Sep 10, 2019
Emerging Company Profile

Trucode: advancing nuclease-free, viral vector-independent gene therapy

...nucleic acid (PNA) technology from Peter Glazer’s lab at Yale University. In 2006, Glazer co-founded Helix...
...a non-exclusive license to the gene editing technology, but the company is no longer active. “Helix...
...and zinc finger nucleases (ZFNs). Instead of cutting the DNA, PNAs open up DNA’s double-stranded helix...
BioCentury | Aug 29, 2019
Distillery Techniques

Counting uninterrupted CAG triplets in HTT gene to predict age of onset for Huntington disease

...Aug. 8, 2019 doi: 10.1016/j.cell.2019.06.036 CONTACT: James F. Gusella, Harvard Medical School, Boston, Mass. e-mail: gusella@helix.mgh.harvard.edu...
BioCentury | Aug 1, 2019
Product Development

NeuBase takes antisense oligos to more targets in more places

...start, a right-handed helical structure complimentary to that of an RNA hairpin or a DNA double-helix...
BioCentury | Nov 28, 2018
Emerging Company Profile

Cybrexa: pH-based tumor targeting

...cancer agent to a pH-sensitive peptide via an undisclosed linker. The peptide forms a transmembrane α-helix...
BioCentury | Nov 16, 2018
Clinical News

BioCardia's CardiAMP non-significantly improves 6MWD in roll-in cohort of Phase III for heart failure

...CardiAMP, which comprises autologous bone marrow-derived cells delivered into the heart muscle using the company's Helix...
...Molecular target: NA Description: Autologous bone marrow-derived cells delivered into the heart muscle using the Helix...
BioCentury | Nov 2, 2018
Targets & Mechanisms

FDA’s pediatric target picks

...include transcriptional repressors containing ankyrin repeat domains or zinc finger domains; transcriptional activators containing basic helix-loop-helix...
BioCentury | Sep 26, 2018
Distillery Therapeutics

Neurology

...online Sept. 7, 2018 doi:10.1126/science.aan8821 CONTACT: Rudolph E. Tanzi, Massachusetts General Hospital, Charlestown, Mass. email: tanzi@helix.mgh.harvard.edu Jennie...
BioCentury | Jul 31, 2018
Translation in Brief

Satellite damage

...replication and repair at replication forks, which are structures that form when the DNA double helix...
BioCentury | May 18, 2018
Financial News

Stapled peptide company FOG raises $66M series B

...chemical bridge, the staple, that stabilizes the core alpha-helix, enhancing the binding affinity of the helix...
Items per page:
1 - 10 of 369
BioCentury | Jun 11, 2020
Deals

Prism’s peptide mimetic platform finds second discovery partner

...Ingelheim GmbH, which has options to license and develop any resulting compounds. Prism’s library comprises α-helix...
...estimate which part of the target protein’s amino acid sequence is likely to form a helix...
BioCentury | Sep 10, 2019
Emerging Company Profile

Trucode: advancing nuclease-free, viral vector-independent gene therapy

...nucleic acid (PNA) technology from Peter Glazer’s lab at Yale University. In 2006, Glazer co-founded Helix...
...a non-exclusive license to the gene editing technology, but the company is no longer active. “Helix...
...and zinc finger nucleases (ZFNs). Instead of cutting the DNA, PNAs open up DNA’s double-stranded helix...
BioCentury | Aug 29, 2019
Distillery Techniques

Counting uninterrupted CAG triplets in HTT gene to predict age of onset for Huntington disease

...Aug. 8, 2019 doi: 10.1016/j.cell.2019.06.036 CONTACT: James F. Gusella, Harvard Medical School, Boston, Mass. e-mail: gusella@helix.mgh.harvard.edu...
BioCentury | Aug 1, 2019
Product Development

NeuBase takes antisense oligos to more targets in more places

...start, a right-handed helical structure complimentary to that of an RNA hairpin or a DNA double-helix...
BioCentury | Nov 28, 2018
Emerging Company Profile

Cybrexa: pH-based tumor targeting

...cancer agent to a pH-sensitive peptide via an undisclosed linker. The peptide forms a transmembrane α-helix...
BioCentury | Nov 16, 2018
Clinical News

BioCardia's CardiAMP non-significantly improves 6MWD in roll-in cohort of Phase III for heart failure

...CardiAMP, which comprises autologous bone marrow-derived cells delivered into the heart muscle using the company's Helix...
...Molecular target: NA Description: Autologous bone marrow-derived cells delivered into the heart muscle using the Helix...
BioCentury | Nov 2, 2018
Targets & Mechanisms

FDA’s pediatric target picks

...include transcriptional repressors containing ankyrin repeat domains or zinc finger domains; transcriptional activators containing basic helix-loop-helix...
BioCentury | Sep 26, 2018
Distillery Therapeutics

Neurology

...online Sept. 7, 2018 doi:10.1126/science.aan8821 CONTACT: Rudolph E. Tanzi, Massachusetts General Hospital, Charlestown, Mass. email: tanzi@helix.mgh.harvard.edu Jennie...
BioCentury | Jul 31, 2018
Translation in Brief

Satellite damage

...replication and repair at replication forks, which are structures that form when the DNA double helix...
BioCentury | May 18, 2018
Financial News

Stapled peptide company FOG raises $66M series B

...chemical bridge, the staple, that stabilizes the core alpha-helix, enhancing the binding affinity of the helix...
Items per page:
1 - 10 of 369